M353-0039

Chemical Structure : M353-0039

Catalog No.: PC-26596Not For Human Use, Lab Use Only.

M353-0039 is a highly potent and selective inhibitor of urea transporter UT-A2 with IC50 of 0.35 uM, shows no detective activity against UT-A3 or UT-B.

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Biological Activity

M353-0039 is a highly potent and selective inhibitor of urea transporter UT-A2 with IC50 of 0.35 uM, shows no detective activity against UT-A3 or UT-B.
M353-0039 exhibited no significant inhibition of UT-A1-mediated urea transport.
M353-0039 exerts selective inhibitory effects on UT-A2 within the mouse kidney medulla.
M353-0039 effectively blocks urea transport in HepG2 cells.

Physicochemical Properties

M.Wt	361.43
Formula	C16H15N3O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((2-methyl-5-(4-methylthiazol-2-yl)thiophen-3-yl)amino)-2-oxoethyl)furan-2-carboxamide

References

1. Liu L, et al. Nat Commun. 2026 Apr 20. doi: 10.1038/s41467-026-71834-w.

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M353-0039

Biological Activity

Physicochemical Properties

References

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