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M4076

Chemical Structure : M4076

CAS No.: 2495096-26-7

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M4076 (Lartesertib, M 4076)

Catalog No.: PC-72900Not For Human Use, Lab Use Only.

Lartesertib (M4076) is a higly potent, selective, ATP-competitive inhibitor of ATM kinase with IC50 of 0.2 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Lartesertib (M4076) is a higly potent, selective, ATP-competitive inhibitor of ATM kinase with IC50 of 0.2 nM.
M4076 sensitizes tumor cell lines to radiation therapy in vitro and strongly enhances the anti-tumor activity of ionizing radiation in vivo.

Physicochemical Properties

M.Wt 448.458
Formula C23H21FN6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-(1,3-dimethyl-1H-pyrazol-4-yl)-1-(3-fluoro-5-methoxypyridin-4-yl)-7-methoxy-3-methyl-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one

References

1. Stakyte K, et al. Nat Struct Mol Biol. 2021 Oct;28(10):789-798.

2. Thomas Fuchss, et al. Cancer Res (2019) 79 (13_Supplement): 3500.

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