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Chemical Structure : M4076
Catalog No.: PC-72900Not For Human Use, Lab Use Only.
Lartesertib (M4076) is a higly potent, selective, ATP-competitive inhibitor of ATM kinase with IC50 of 0.2 nM.
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Lartesertib (M4076) is a higly potent, selective, ATP-competitive inhibitor of ATM kinase with IC50 of 0.2 nM.
M4076 sensitizes tumor cell lines to radiation therapy in vitro and strongly enhances the anti-tumor activity of ionizing radiation in vivo.
| M.Wt | 448.458 | |
| Formula | C23H21FN6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stakyte K, et al. Nat Struct Mol Biol. 2021 Oct;28(10):789-798.
2. Thomas Fuchss, et al. Cancer Res (2019) 79 (13_Supplement): 3500.
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