M468-4456 | ULK1 inhibitor | Probechem Biochemicals

Chemical Structure : M468-4456

M468-4456 (Compound U9)

Catalog No.: PC-25237Not For Human Use, Lab Use Only.

M468-4456 (Compound U9) is a small molecule inhibitor of serine/threonine kinase UNC-51-like kinase 1 (ULK1) with IC50 of 305 nM,

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Biological Activity

M468-4456 (Compound U9) is a small molecule inhibitor of serine/threonine kinase UNC-51-like kinase 1 (ULK1) with IC50 of 305 nM,
Compound U9 has a broad-spectrum anticancer effect, especially on A549 cells.
Compound U9 effectively inhibits autophagy and induces apoptosis in A549 cells.

Physicochemical Properties

M.Wt	444.58
Formula	C27H32N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(6-benzyl-2-ethyl-4-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-3(4H)-yl)-N-(3-phenylpropyl)acetamide

References

1. Zhijia Li, et al. Int J Biol Macromol. 2025 Aug 4;321(Pt 3):146532.

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M468-4456 (Compound U9)

Biological Activity

Physicochemical Properties

References

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