M4K2149

Chemical Structure : M4K2149

Catalog No.: PC-22017Not For Human Use, Lab Use Only.

M4K2149 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 17 nM, 34-fold selective over ALK5 (IC50=756 nM).

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Biological Activity

M4K2149 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 17 nM, 34-fold selective over ALK5 (IC50=756 nM).
M4K2149 shows cell IC50 of 55 nM in NanoBRET target engagement assay.
M4K2149 is equipotent against both wild-type (WT) and mutant ALK2 (G328V, R206H, and R258G) in the biochemical kinase assay (IC50=5-9 nM).

Physicochemical Properties

M.Wt	402.50
Formula	C24H26N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methoxy-4-(4-methyl-5-(4-(piperazin-1-yl)phenyl)pyridin-3-yl)benzamide

References

1. Deeba Ensan, et al. J Med Chem. 2020 May 14;63(9):4978-4996.

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M4K2149

Biological Activity

Physicochemical Properties

References

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