M4K2306

Chemical Structure : M4K2306

Catalog No.: PC-22016Not For Human Use, Lab Use Only.

M4K2306 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 7 nM, >500-fold selective over ALK5.

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Biological Activity

M4K2306 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 7 nM, >500-fold selective over ALK5.
M4K2306 shows cell IC50 of 18 nM in NanoBRET target engagement assay.
M4K2306 also shows high selectivity over ALK1 and ALK6, ALK4, as well as favorable kinome-wide selectivity.
M4K2306 demonstrates excellent kinome-wide selectivity, inhibiting only 3% of 422 kinases by more than 50% at 1 uM.

Physicochemical Properties

M.Wt	474.61
Formula	C28H34N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-methyl-9-(4-methylpiperazin-1-yl)-4-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-benzo[c]pyrido[3,4-e]azepine

References

1. González-Álvarez H, et al. J Med Chem. 2024 Mar 18.

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M4K2306

Biological Activity

Physicochemical Properties

References

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