M8891 | MetAP-2 inhibitor | Probechem Biochemicals

Chemical Structure : M8891

CAS No.: 1464842-09-8

M8891 (M 8891)

Catalog No.: PC-73107Not For Human Use, Lab Use Only.

M8891 (M 8891) is an orally bioavailable, potent, and reversible methionine aminopeptidase 2 (MetAP2) inhibitor with IC50 of 54 nM, Ki of 4.33 nM.

Packing	Price	Stock
2 mg	$328	In stock
5 mg	$498	In stock
10 mg	$788	In stock
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Biological Activity

M8891 (M 8891) is an orally bioavailable, potent, and reversible methionine aminopeptidase 2 (MetAP2) inhibitor with IC50 of 54 nM, Ki of 4.33 nM.
M8891 impede the growth of primary endothelial cells and demonstrated antitumoral activity in mouse models.

Physicochemical Properties

M.Wt	385.37
Formula	C20H17F2N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-Hydroxy-1-(1H-indol-5-yl)-2-oxo-pyrrolidine-3-carboxylic Acid 3,5-Difluoro-benzylamide

References

1. Heinrich T, et al. J Med Chem. 2019 Dec 26;62(24):11119-11134.

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M8891 (M 8891)

Biological Activity

Physicochemical Properties

References

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