Chemical Structure : MA9-060
CAS No.:
2413026-03-4
MA9-060
(MA9060, MA9)
Catalog No.: PC-28344Not For Human Use, Lab Use Only.
MA9-060 (MA9) is a potent, seletive small molecule Unc-51 like kinase 3 (ULK3) inhibitor with IC50 of 226 nM, weakerly inhibits ULK1 (IC50=1046 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MA9-060 (MA9) is a potent, seletive small molecule Unc-51 like kinase 3 (ULK3) inhibitor with IC50 of 226 nM, weakerly inhibits ULK1 (IC50=1046 nM).
MA9-060 (MA9) is a type-1 inhibitor that engages the hinge Cys94 residue via hydrogen bonding to its pyrimidine N1 and 2-anilinyl NH groups.
MA9-060 (MA9) provokes rapid reductions in ULK3 levels and autophagy effectors in U266 MM cells, is not toxic to normal primary human MSCs. inhibit the proper formation of autophagolysosomes.
MA9-060 (MA9) significantly reduces MM growth and myeloma-associated bone disease in vivo, is sensitive for drug-resistant MM cells express increased levels of ULK3.
MA9-060 (MA9) displays potent anti-myeloma activity against patient derived MM cells ex vivo.
Physicochemical Properties
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M.Wt
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561.12
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Formula
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C27H34ClFN6O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2-chloro-5-((2-((3-fluoro-4-(1-methylpiperidin-4-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)phenyl)-2-methylpropane-2-sulfonamide
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References
1. Tauro M, et al. Nat Commun. 2026 Aug 25;17(1):10142.
2. Patent WO2022155593 A1 2022-07-21.
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