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Chemical Structure : MAC-545496
CAS No.: 838810-96-1
Catalog No.: PC-72426Not For Human Use, Lab Use Only.
MAC-545496 (MAC545496) is an antivirulence compound that reverses β-lactam resistance in the community-acquired MRSA USA300 strain via inhibition on GraR function (Kd<0.1 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | Get quote |
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MAC-545496 (MAC545496) is an antivirulence compound that reverses β-lactam resistance in the community-acquired MRSA USA300 strain via inhibition on GraR function (Kd<0.1 nM).
MAC-545496 could also serve as an antivirulence agent alone.
MAC-545496 attenuates MRSA virulence in Galleria mellonella larvae.
MAC-545496 inhibits biofilm formation and abrogates intracellular survival in macrophages.
GraR is a regulator that responds to cell-envelope stress and is an important virulence factor and determinant of antibiotic resistance.
MAC-545496 has value as a research tool to probe the GraXRS regulatory system and as an antibacterial lead series of a mechanism to combat drug-resistant Staphylococcal infections.
| M.Wt | 419.884 | |
| Formula | C18H18ClN5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide |
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1. Omar M El-Halfawy, et al. Nat Chem Biol. 2020 Feb;16(2):143-149.
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