MAD2L2 inhibitor C3 (C#3, ZINC25496030)

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Chemical Structure : MAD2L2 inhibitor C3

Catalog No.: PC-27690Not For Human Use, Lab Use Only.

MAD2L2 inhibitor C#3 (ZINC25496030) is a small-molecule inhibitor of DNA polymerase Pol ζ (zeta) regulatory subunit MAD2L2 (Rev7), disrupts the MAD2L2-Rev1 interaction, potentially causes mutagenic translesion synthesis (TLS) inhibition, sensitizes lung cancer cell lines to cisplatin.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MAD2L2 inhibitor C#3 (ZINC25496030) is a small-molecule inhibitor of DNA polymerase Pol ζ (zeta) regulatory subunit MAD2L2 (Rev7), disrupts the MAD2L2-Rev1 interaction, potentially causes mutagenic translesion synthesis (TLS) inhibition, sensitizes lung cancer cell lines to cisplatin.

Physicochemical Properties

M.Wt	342.35
Formula	C18H18N2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-2-(2-(2-(furan-2-yl)-5-methyl-4,5-dihydrooxazol-4-yl)acetamido)-2-phenylacetic acid

References

1. Pernicone N, et al. (2022) Molecules 27 (3), 636.

2. Ayiku PJ, et al. Front Cell Dev Biol. 2026 Jul 29;14:1859193.

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