MAN-021 | NPC molecular glue degrader | Probechem Biochemicals

Chemical Structure : MAN-021

MAN-021 (MAN021)

Catalog No.: PC-26895Not For Human Use, Lab Use Only.

MAN-021 is a potent TRIM21-NUP98 molecular glue triggering nuclear pore complex (NPC) degradation, promotes TRIM21 to bind the nuclear pore protein NUP98, inhibits PANC-1 cell proliferation with EC50 of 1.9 nM.

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Biological Activity

Physicochemical Properties

M.Wt	459.95
Formula	C23H27ClFN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-chloro-2-(2-(dimethylamino)ethoxy)phenyl)-6-fluoro-2-(piperazin-1-ylmethyl)quinazolin-4(3H)-one

References

1. Hinshaw SM, et al. Cell Chem Biol. 2026 May 27:S2451-9456(26)00151-0.

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MAN-021 (MAN021)

Biological Activity

Physicochemical Properties

References

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