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MAO B inhibitor compound 1

Chemical Structure : MAO B inhibitor compound 1

CAS No.: 3049652-54-9

MAO B inhibitor compound 1

Catalog No.: PC-26555Not For Human Use, Lab Use Only.

MAO B inhibitor compound 1 is a potent, BBB-penetrant monoamine oxidase B (MAO B, MAO-B) inhibitor with IC50 of 52 nM, shows antioxidant and neuroprotective properties.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MAO B inhibitor compound 1 is a potent, BBB-penetrant monoamine oxidase B (MAO B, MAO-B) inhibitor with IC50 of 52 nM, shows antioxidant and neuroprotective properties.
MAO B inhibitor compound 1 shows low activity toward MAO A (14% inhibition at 10 μM concentration, IC50 > 10 μM).

Physicochemical Properties

M.Wt 458.47
Formula C25H22N4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(1H-indazol-5-yl)-3-(4-((3,4,5-trimethoxybenzyl)oxy)phenyl)-1,2,4-oxadiazole

References

1. Mastrogiacomo R, et al. Mol Pharm. 2026 Apr 10. doi: 10.1021/acs.molpharmaceut.5c01754.

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