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Chemical Structure : MAP3K14-IN-173
Catalog No.: PC-60165Not For Human Use, Lab Use Only.
MAP3K14-IN-173 is a novel potent MAP3K14 kinase (NF-κB-inducing kinase, NIK) inhibitor with IC50 of 1.8 nM (NIK autophosphorylation).
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MAP3K14-IN-173 is a novel potent MAP3K14 kinase (NF-κB-inducing kinase, NIK) inhibitor with IC50 of 1.8 nM (NIK autophosphorylation).
MAP3K14-IN-173 inhibits p-IKKα levels of L363 (NIK translocated multiple myeloma) cells with IC50 of 1.3 nM.
MAP3K14-IN-173 exhibits antiproliferative activity on JJN-3 (NIK translocated) multiple myeloma cells (IC50=29 nM).
| M.Wt | 509.614 | |
| Formula | C29H31N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kargbo RB, et al. ACS Med Chem Lett. 2017 Aug 17;8(9):908-910.
2. Patent WO2017125530 A1, compound example 173.
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