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MAP3K14-IN-173

Chemical Structure : MAP3K14-IN-173

CAS No.: 2113617-02-8

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MAP3K14-IN-173 (MAP3K14 inhibitor, NIK inhibitor)

Catalog No.: PC-60165Not For Human Use, Lab Use Only.

MAP3K14-IN-173 is a novel potent MAP3K14 kinase (NF-κB-inducing kinase, NIK) inhibitor with IC50 of 1.8 nM (NIK autophosphorylation).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MAP3K14-IN-173 is a novel potent MAP3K14 kinase (NF-κB-inducing kinase, NIK) inhibitor with IC50 of 1.8 nM (NIK autophosphorylation).
    MAP3K14-IN-173 inhibits p-IKKα levels of L363 (NIK translocated multiple myeloma) cells with IC50 of 1.3 nM.
    MAP3K14-IN-173 exhibits antiproliferative activity on JJN-3 (NIK translocated) multiple myeloma cells (IC50=29 nM).

    Physicochemical Properties

    M.Wt 509.614
    Formula C29H31N7O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-5-(2-((5-cyano-2-methyl-4-(2-morpholinoethyl)phenyl)amino)pyrimidin-4-yl)-3-(hydroxymethyl)-3-methylindoline-7-carbonitrile

    References

    1. Kargbo RB, et al. ACS Med Chem Lett. 2017 Aug 17;8(9):908-910.

    2. Patent WO2017125530 A1, compound example 173.

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