MAP3K1 inhibitor 51-106

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Chemical Structure : MAP3K1 inhibitor 51-106

Catalog No.: PC-24647Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MAP3K1 inhibitor 51-106 is a selective MAP3K1 inhibitor with IC50 of 1.8 uM in in MAP3K1 WT cells, binds to MAP3K1 and blocks IKKβ phosphorylation, resulting in the inhibition of TNF-α-induced NF-κB activation.
51-106 does not inhibit MAP3K6 or MAP3K15 and inhibited MAP3K2, MAP3K3, MAP3K4, and MAP3K5 at a low level (4.6%, 11.4%, 8.6%, and 11.7%, respectively, at 5 uM).
51-106 also does not inhibit MAP3K1 substrates IKKβ and MAP2K4.

Physicochemical Properties

M.Wt	430.37
Formula	C20H14F4N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-(1-methyl-1H-pyrazol-4-yl)quinoxalin-6-yl)urea

References

1. Patent WO 2011/135376 A1, 2011.

2. Boghean L, et al. Molecules. 2025 Apr 30;30(9):2001.

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