MAP4K4 inhibitor 15f

Chemical Structure : MAP4K4 inhibitor 15f

Catalog No.: PC-26554Not For Human Use, Lab Use Only.

MAP4K4 inhibitor 15f is a potent, selective inhibitor of MAP4K4 with IC50 of 89 nM, shows neuroprotective effects.

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Biological Activity

MAP4K4 inhibitor 15f is a potent, selective inhibitor of MAP4K4 with IC50 of 89 nM, shows neuroprotective effects.
MAP4K4 inhibitor 15f increased the viability of motor neurons in a dose-dependent manner.
MAP4K4 inhibitor 15f reduced the c-Jun phosphorylation level in a dose-dependent manner on SOD1 mutant ALS patient-derived iPSC-MNs.

Physicochemical Properties

M.Wt	343.32
Formula	C14H12F3N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-methyl-5-(4-(trifluoromethyl)phenyl)-3-ureidothiophene-2-carboxamide

References

1. Hattori H, et al. Bioorg Med Chem Lett. 2024 Nov 15;113:129935.

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