Catalog No.: PC-20583Not For Human Use, Lab Use Only.
MBX2329 is a small molecule inhibitor of influenza virus via targeting influenza hemagglutinin (HA), specifically inhibits HA-mediated viral entry with potent antiviral activity against different influenza virus strains (IC50=0.3-5.9 uM).
MBX2329 is a small molecule inhibitor of influenza virus via targeting influenza hemagglutinin (HA), specifically inhibits HA-mediated viral entry with potent antiviral activity against different influenza virus strains (IC50=0.3-5.9 uM). MBX2329 binds to HA in a nonoverlapping manner, binds to the group 1 HA-specific conformational epitope in the HA stem region. MBX2329 displays little inhibitory activity against HIV/LASV-GP, HIV/EBOV-GP, or HIV/VSV-G with IC50 values >100 uM. MBX2329 inhibits influenza A H1N1 virus strains A/PR/8/34 (H1N1), A/Florida/21/2008 (H1N1-H275Y) (oseltamivir-resistant strain), A/Washington/10/2008 (H1N1), and A/California/10/2009 (H1N1) (2009 pandemic strain) with IC50s of 0.29 μM- 0.53 μM. MBX2329 displays significantly less activity against influenza A H3N2 virus strain A/Texas/12/2007 (H3N2) and influenza B virus strain B/Florida/4/2006. MBX2329 specifically inhibits influenza viruses of group 1 HA (H1 and H5 subtypes), but not group 2 HA (H3 and H7 subtypes). MBX2329 exhibit strong synergy with oseltamivir.
Physicochemical Properties
M.Wt
283.84
Formula
C16H26ClNO
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
CCC1=CC=CC=C1OCCN2CCCCCC2.[H]Cl
References
1. Basu A, et al. J Virol. 2014 Feb;88(3):1447-60.
