Catalog No.: PC-47106Not For Human Use, Lab Use Only.
MBZM-N-IBT is a small molecule inhibitor of Chikungunya virus (CHIKV), inhibits CHIKV infection in vitro in RAW 264.7 cells with IC50 of 22.34 uM, targets CHIKV nsP2 protease activity.
MBZM-N-IBT is a small molecule inhibitor of Chikungunya virus (CHIKV), inhibits CHIKV infection in vitro in RAW 264.7 cells with IC50 of 22.34 uM, targets CHIKV nsP2 protease activity.
MBZM-N-IBT predominately interfered in the early stages of CHIKV life cycle, diminished the CHIKV-induced inflammatory responses in vitro through significant downregulation of all the major mitogen-activated protein kinases (MAPKs), NF-κB, cyclooxygenase (COX)-2, and cytokines.
MBZM-N-IBT restricted CHIKV infection and inflammation in vivo, leading to reduced clinical scores and complete survival of C57BL/6 mice.
MBZM-N-IBT also remarkably reduced CHIKV infection in hPBMC-derived monocyte-macrophage populations ex vivo.
