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Chemical Structure : MBZM-N-IBT
Catalog No.: PC-47106Not For Human Use, Lab Use Only.
MBZM-N-IBT is a small molecule inhibitor of Chikungunya virus (CHIKV), inhibits CHIKV infection in vitro in RAW 264.7 cells with IC50 of 22.34 uM, targets CHIKV nsP2 protease activity.
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MBZM-N-IBT is a small molecule inhibitor of Chikungunya virus (CHIKV), inhibits CHIKV infection in vitro in RAW 264.7 cells with IC50 of 22.34 uM, targets CHIKV nsP2 protease activity.
MBZM-N-IBT predominately interfered in the early stages of CHIKV life cycle, diminished the CHIKV-induced inflammatory responses in vitro through significant downregulation of all the major mitogen-activated protein kinases (MAPKs), NF-κB, cyclooxygenase (COX)-2, and cytokines.
MBZM-N-IBT restricted CHIKV infection and inflammation in vivo, leading to reduced clinical scores and complete survival of C57BL/6 mice.
MBZM-N-IBT also remarkably reduced CHIKV infection in hPBMC-derived monocyte-macrophage populations ex vivo.
| M.Wt | 364.427 | |
| Formula | C18H16N6OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Saikat De, et al. Antimicrob Agents Chemother. 2022 Jun 29;e0046322.
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