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MC-100093

Chemical Structure : MC-100093

CAS No.: 1639784-02-3

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MC-100093 (MC100093)

Catalog No.: PC-72279Not For Human Use, Lab Use Only.

MC-100093 (MC100093) is a potent, orally bioavailable upregulator of glutamate transporter-1 (GLT-1) and devoid of antimicrobial properties.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MC-100093 (MC100093) is a potent, orally bioavailable upregulator of glutamate transporter-1 (GLT-1) and devoid of antimicrobial properties.
    MC-100093 enhanced uptake of glutamate into astrocytes in a mouse neuron/astrocyte co-culture model with IC50 of 0.1 uM.
    MC-100093 restored the expression of NA core GLT-1.
    MC-100093 (50 mg/kg) attenuated cue-primed relapse to cocaine-seeking without reducing motivation to consume regular chow or sucrose pellets or affecting body weight.

    Physicochemical Properties

    M.Wt 269.345
    Formula C13H23N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3S,4R)-3-((R)-1-hydroxyethyl)-4-((R)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl)azetidin-2-one

    References

    1. Lori A Knackstedt, et al. J Pharmacol Exp Ther. 2021 Aug;378(2):51-59.

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