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Chemical Structure : MC1575
Catalog No.: PC-63087Not For Human Use, Lab Use Only.
MC1575 is a potent and selective class IIa HDAC inhibitor with IC50 of 440 nM for maize HD1-A, displays >70-fold selectivity over HD1-B.
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MC1575 is a potent and selective class IIa HDAC inhibitor with IC50 of 440 nM for maize HD1-A, displays >70-fold selectivity over HD1-B.
MC1575 exhibits a dose-dependent antiproliferative effect and induces cell cycle arrest although this blockade occurred at a different level than TSA.
MC1575 increases p21(waf1/CIP1) mRNA levels and induces ERbeta gene expression.
MC1575 also suppress IL-8 expression in human melanoma cells.
| M.Wt | 330.77 | |
| Formula | C17H15ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mai A, et al. J Med Chem. 2005 May 5;48(9):3344-53.
2. Duong V, et al. Mol Cancer Res. 2008 Dec;6(12):1908-19.
3. Venza I, et al. Pigment Cell Melanoma Res. 2013 Mar;26(2):193-204.
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