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MC2884

Chemical Structure : MC2884

CAS No.: 330657-42-6

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MC2884 (MC 2884;MC-2884 )

Catalog No.: PC-35191Not For Human Use, Lab Use Only.

MC2884 is a novel hybrid, dual HAT/EZH2 inhibitor with IC50 of 3.27, 8.35 and 4.56 uM for CBP, KAT5 and p300, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MC2884 is a novel hybrid, dual HAT/EZH2 inhibitor with IC50 of 3.27, 8.35 and 4.56 uM for CBP, KAT5 and p300, respectively.
    MC2884 induces caspase- and mitochondrial-dependent cancer-selective apoptosis on a variety of cancers, accompanied by ROS production.
    MC2884 displays anticancer action in both hematological and solid cancer in vivo models, induces apoptosis in aggressive cancers and in primary leukemic blasts, also synergizes with BCL2 inhibitors.

    Physicochemical Properties

    M.Wt 523.268
    Formula C26H21Br2NO
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-benzyl-3,5-bis((E)-3-bromobenzylidene)piperidin-4-one

    References

    1. Petraglia F, et al. Oncotarget. 2018 May 22;9(39):25630-25646.

    2. Singh AA, et al. Oncotarget. 2018 May 22;9(39):25647-25660.

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