MCHR2 antagonist 38

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Chemical Structure : MCHR2 antagonist 38

Catalog No.: PC-22723Not For Human Use, Lab Use Only.

MCHR2 antagonist 38 is a potent and specific MCH receptor subtype 2 (MCHR2) antagonist with IC50 of 1 nM in MCHR2 Ca+2 FLIPR assay, Ki of 13 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MCHR2 antagonist 38 is a potent and specific MCH receptor subtype 2 (MCHR2) antagonist with IC50 of 1 nM in MCHR2 Ca+2 FLIPR assay, Ki of 13 nM.
MCHR2 antagonist 38 shows a very good selectivity against MCHR1 with no detectable MCHR1 activity in the MCHR1 FLIPR assay up to 50 μM or a MCHR1 binding assay up to 10 μM.
MCHR2 antagonist 38 displays 500-fold selectivity in a panel of 23 receptors in MDS-PanLabs.
MCHR2 antagonist 38 also demonstrates good pharmacokinetic properties across rat, beagle dog and rhesus monkey.

Physicochemical Properties

M.Wt	466.59
Formula	C29H30N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-((3-acetamido-2,3-dihydrospiro[indene-1,4'-piperidin]-1'-yl)methyl)-9H-carbazole-9-carboxamide

References

1. Xiaoqi Chen, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):363-6.

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