Catalog No.: PC-26682Not For Human Use, Lab Use Only.
MCOPPB trihydrochloride is potent, selective nociceptin/orphanin FQ peptide receptor (NOP receptor) with pKi of 10.07, shows 12-, 270- and >1000-fold selectivity over opioid receptors micro-, kappa-, and delta-receptor, respectively.
MCOPPB trihydrochloride is potent, selective nociceptin/orphanin FQ peptide receptor (NOP receptor) with pKi of 10.07, shows 12-, 270- and >1000-fold selectivity over opioid receptors micro-, kappa-, and delta-receptor, respectively. MCOPPB (10 mg/kg, p.o.) inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. MCOPPB (10 mg/kg, p.o.) and diazepam (3 mg/kg, p.o.) elicited anxiolytic-like effects in mouse Vogel conflict test. MCOPPB at an oral dose of 10 mg/kg did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.
