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MDI-2268

Chemical Structure : MDI-2268

CAS No.: 1609176-50-2

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MDI-2268 (MDI2268)

Catalog No.: PC-35871Not For Human Use, Lab Use Only.

MDI-2268 (MDI2268) is a small-molecule, in vivo-active inhibitor of plasminogen activator inhibitor type-1 (PAI-1), demonstrates excellent pharmacokinetics, potent activity against vitronectin-bound PAI-1 in vivo, and efficacy in murine model of venous thrombosis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MDI-2268 (MDI2268) is a small-molecule, in vivo-active inhibitor of plasminogen activator inhibitor type-1 (PAI-1), demonstrates excellent pharmacokinetics, potent activity against vitronectin-bound PAI-1 in vivo, and efficacy in murine model of venous thrombosis.

    Physicochemical Properties

    M.Wt 277.203
    Formula C10H10F3N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-hydrazinyl-2-oxo-N-(3-(trifluoromethoxy)benzyl)acetamide

    References

    1. Reinke AA, et al. J Biol Chem. 2018 Dec 3. pii: jbc.RA118.004885. doi: 10.1074/jbc.RA118.004885.

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