MDI-2268 | PAI-1 inhibitor | Probechem Biochemicals

Chemical Structure : MDI-2268

MDI-2268 (MDI2268)

Catalog No.: PC-35871Not For Human Use, Lab Use Only.

MDI-2268 (MDI2268) is a small-molecule, in vivo-active inhibitor of plasminogen activator inhibitor type-1 (PAI-1), demonstrates excellent pharmacokinetics, potent activity against vitronectin-bound PAI-1 in vivo, and efficacy in murine model of venous thrombosis.

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Biological Activity

MDI-2268 (MDI2268) is a small-molecule, in vivo-active inhibitor of plasminogen activator inhibitor type-1 (PAI-1), demonstrates excellent pharmacokinetics, potent activity against vitronectin-bound PAI-1 in vivo, and efficacy in murine model of venous thrombosis.

Physicochemical Properties

M.Wt	277.203
Formula	C10H10F3N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-hydrazinyl-2-oxo-N-(3-(trifluoromethoxy)benzyl)acetamide

References

1. Reinke AA, et al. J Biol Chem. 2018 Dec 3. pii: jbc.RA118.004885. doi: 10.1074/jbc.RA118.004885.

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MDI-2268 (MDI2268)

Biological Activity

Physicochemical Properties

References

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