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MDL-29951

Chemical Structure : MDL-29951

CAS No.: 130798-51-5

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MDL-29951 (MDL 29,951, MDL29951)

Catalog No.: PC-23317Not For Human Use, Lab Use Only.

MDL-29951 (MDL-29, 951) is a potent glycine antagonist of NMDA receptor with Ki of 0.14 uM for [3H]glycine binding in vitro, also is a potent GPR17 agonist with pEC50 of 6.48.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MDL-29951 (MDL-29, 951) is a potent glycine antagonist of NMDA receptor with Ki of 0.14 uM for [3H]glycine binding in vitro, also is a potent GPR17 agonist with pEC50 of 6.48.

Physicochemical Properties

M.Wt 302.11
Formula C12H9Cl2NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid

References

1. Baron BM, et al. J Pharmacol Exp Ther. 1992 Sep;262(3):947-56.

2. Wright SW, et al. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8.

3. Stephanie Hennen, et al. Sci Signal. 2013 Oct 22;6(298):ra93.

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