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MDL100907

Chemical Structure : MDL100907

CAS No.: 139290-65-6

MDL100907 (MDL-100907;MDL100907;Volinanserin)

Catalog No.: PC-60814Not For Human Use, Lab Use Only.

MDL100907 (Volinanserin) is a potent, selective 5-HT2A receptor antagonist with Ki of 0.36 nM, > 80-fold selectivity for 5-HT2A over other serotonergic receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MDL100907 (Volinanserin) is a potent, selective 5-HT2A receptor antagonist with Ki of 0.36 nM, > 80-fold selectivity for 5-HT2A over other serotonergic receptors.
MDL100907 demonstrates a clozapine-like profile of potential antipsychotic activity with low extrapyramidal sid-effect liability, and has a superior CNS safety index.

Physicochemical Properties

M.Wt 373.46
Formula C22H28FNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol

References

1. Ardayfio PA, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):891-7.

2. Sorensen SM, et al. J Pharmacol Exp Ther. 1993 Aug;266(2):684-91.

3. Kehne JH, et al. J Pharmacol Exp Ther. 1996 May;277(2):968-81.

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