MDL28170 is a potent, selective and membrane-permeable cysteine protease inhibitor of calpain, also blocks γ-secretase activity.
MDL-28170 significantly and time-dependently improves the recovery of synaptic responses in hippocampal slices following prolonged, moderate hypoxia without hypoxic depolarization.
MDL-28170 dose-dependently inhibits brain cysteine proteinase activity with Ki of 10 nM.
MDL-28170 (50 mg/kg, i.p.) completely prevents the striatal damage in vivo.
MDL-28170 (30 mg/kg, i.p.) reduces the functional and structural deterioration of corpus callosum following fluid percussion injury.
