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Chemical Structure : MDL28170
CAS No.: 88191-84-8
Catalog No.: PC-20599Not For Human Use, Lab Use Only.
MDL28170 is a potent, selective and membrane-permeable cysteine protease inhibitor of calpain, also blocks γ-secretase activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | Get quote |
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MDL28170 is a potent, selective and membrane-permeable cysteine protease inhibitor of calpain, also blocks γ-secretase activity.
MDL-28170 significantly and time-dependently improves the recovery of synaptic responses in hippocampal slices following prolonged, moderate hypoxia without hypoxic depolarization.
MDL-28170 dose-dependently inhibits brain cysteine proteinase activity with Ki of 10 nM.
MDL-28170 (50 mg/kg, i.p.) completely prevents the striatal damage in vivo.
MDL-28170 (30 mg/kg, i.p.) reduces the functional and structural deterioration of corpus callosum following fluid percussion injury.
| M.Wt | 382.46 | |
| Formula | C22H26N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzyl ((2S)-3-methyl-1-oxo-1-((1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate |
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1. Chen ZF, et al. Brain Res. 1997 Sep 19;769(1):188-92.
2. Li PA, et al. Neurosci Lett. 1998 May 8;247(1):17-20.
3. De Strooper B, et al. Nature. 1999 Apr 8;398(6727):518-22.
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