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Chemical Structure : MDVN-1003
Catalog No.: PC-60272Not For Human Use, Lab Use Only.
MDVN-1003 (MDVN1003) is a first-in-class, selective, orally bioavailable, dual inhibitor of BTK and PI3Kδ kinases with IC50 of 32.3 nM and 16.9 nM, respectively.
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MDVN-1003 (MDVN1003) is a first-in-class, selective, orally bioavailable, dual inhibitor of BTK and PI3Kδ kinases with IC50 of 32.3 nM and 16.9 nM, respectively.
MDVN-1003 inhibits B cell activation upon BCR cross-linking ex vivo and in vivo, induces apoptosis and decreases viability of DOHH-2 cells.
MDVN-1003 shows significant anti-tumor effects in an NHL xenograft model in mice.
| M.Wt | 417.45 | |
| Formula | C22H20FN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Alfaro J, et al. J Pharmacol Exp Ther. 2017 May;361(2):312-321.
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