Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ME0328
CAS No.: 1445251-22-8
Catalog No.: PC-35508Not For Human Use, Lab Use Only.
ME0328 (ME-0328) is a potent, selective inhibitor of ADP-ribosyltransferase ARTD3/PARP3 with IC50 of 0.89 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ME0328 (ME-0328) is a potent, selective inhibitor of ADP-ribosyltransferase ARTD3/PARP3 with IC50 of 0.89 uM.
ME0328 displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50=6.3, 10.8 and >30 uM respectively).
ME0328 potentiates vinorelbine sensitization in breast cancer cell lines at the G2/M boundary, also potentiates vinorelbine-induced PARP3 inhibition, mitotic arrest, and apoptosis.
| M.Wt | 321.38 | |
| Formula | C19H19N3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide |
|
1. Lindgren AE, et al. ACS Chem Biol. 2013 Aug 16;8(8):1698-703.
2. Sharif-Askari B, et al. Breast Cancer Res Treat. 2018 Jul 23. doi: 10.1007/s10549-018-4888-6.
3. Wang H, et al. Cancer Lett. 2017 Jan 28;385:137-143.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
