ME3183 | PDE4 inhibitor | Probechem Biochemicals

Chemical Structure : ME3183

ME3183 (ME 3183)

Catalog No.: PC-21464Not For Human Use, Lab Use Only.

ME3183 is a potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 2.33, 1.28 and 1.63 nM for PDE4B1, PDE4A1A and PDE4D2 respectively.

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Biological Activity

ME3183 is a potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 2.33, 1.28 and 1.63 nM for PDE4B1, PDE4A1A and PDE4D2 respectively.
ME3183 exhibits >194-fold selectivity over other PDEs.
ME3183 potently inhibits LPS-induced TNF-α, IL-12/23p40, and IL-23 production in PBMCs with IC50 of 0.648, 1.96 and 98.4 nM respectively.
ME3183 provides superior inhibition of the production of psoriasis-related cytokines, such as TNF-α, IL-12/23p40, IL-23, and IL-17A, by human PBMCs and T cells, compared with apremilast, roflumilast, and crisaborole.
ME3183 provides superior inhibition of the production of Th2 cytokines, such as IL-4, IL-5, and IL-13, by human T cells.
ME3183 inhibits ear swelling and cytokine production in skin lesions of mice with chronic oxazolone-induced dermatitis with ED50 of 1.43 mg/kg.

Physicochemical Properties

M.Wt	422.45
Formula	C19H20F2N4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((2-(3,6-diazabicyclo [3.1.1]heptan-3-yl)-7-(thiazol-2-yl)benzo [d]oxazol-4-yl)oxy)-1,1-difluoro-2-methylpropan-2-ol

References

1. Kubota-Ishida N, et al. Eur J Pharmacol. 2023 Nov 22;962:176202.

ME3183 (ME 3183)

Biological Activity

Physicochemical Properties

References

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