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Chemical Structure : MEDS433
Catalog No.: PC-72691Not For Human Use, Lab Use Only.
MEDS433 is a potent DHODH inhibitor with IC50 of 1.2 nM (hDHODH), inhibits in vitro replication of HSV-1 and HSV-2 in the nanomolar range.
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MEDS433 is a potent DHODH inhibitor with IC50 of 1.2 nM (hDHODH), inhibits in vitro replication of HSV-1 and HSV-2 in the nanomolar range.
MEDS433 targets the de novo pyrimidine biosynthesis.
MEDS433 exhibited highly synergistic antiviral activity when combined with acyclovir and dipyridamole.
MEDS433 is a promising candidate as either single agent or in combination regimens with existing direct-acting anti-HSV drugs.
| M.Wt | 401.321 | |
| Formula | C20H11F4N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Luganini A, et al. Antiviral Res. 2021 May;189:105057.
2. Stefano Sainas, et al. J Med Chem. 2018 Jul 26;61(14):6034-6055.
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