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MEDS433

Chemical Structure : MEDS433

CAS No.: 2241027-61-0

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MEDS433 (MEDS-433)

Catalog No.: PC-72691Not For Human Use, Lab Use Only.

MEDS433 is a potent DHODH inhibitor with IC50 of 1.2 nM (hDHODH), inhibits in vitro replication of HSV-1 and HSV-2 in the nanomolar range.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MEDS433 is a potent DHODH inhibitor with IC50 of 1.2 nM (hDHODH), inhibits in vitro replication of HSV-1 and HSV-2 in the nanomolar range.
MEDS433 targets the de novo pyrimidine biosynthesis.
MEDS433 exhibited highly synergistic antiviral activity when combined with acyclovir and dipyridamole.
MEDS433 is a promising candidate as either single agent or in combination regimens with existing direct-acting anti-HSV drugs.

Physicochemical Properties

M.Wt 401.321
Formula C20H11F4N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-hydroxy-N-(2,3,5,6-tetrafluoro-[1,1'-biphenyl]-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

References

1. Luganini A, et al. Antiviral Res. 2021 May;189:105057.

2. Stefano Sainas, et al. J Med Chem. 2018 Jul 26;61(14):6034-6055.

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