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Chemical Structure : MELK-T1 hydrochloride
CAS No.: 1610536-69-0
Catalog No.: PC-70139Not For Human Use, Lab Use Only.
MELK-T1 (JNJ-47117096) hydrochloride is a cell-permeable, potent and selective inhibitor of MELK kinase domain with IC50 of 37 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
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| 100 mg | Get quote |
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MELK-T1 (JNJ-47117096) hydrochloride is a cell-permeable, potent and selective inhibitor of MELK kinase domain with IC50 of 37 nM.
MELK-T1 shows >50% inhibition at 1 uM against 6 kianses in a panel of 235 kinases (Flt3 IC50=18 nM);.
MELK-T1 triggers a rapid and proteasome-dependent degradation of the MELK protein, induces the accumulation of stalled replication forks and DSBs in MCF-7 cells.
MELK-T1 induces a strong phosphorylation of p53, a prolonged up-regulation of p21 and a down-regulation of FOXM1 target genes.
| M.Wt | 398.891 | |
| Formula | C21H23ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-methoxy-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)benzamide hydrochloride |
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1. Beke L, et al. Biosci Rep. 2015 Oct 2;35(6). pii: e00267.
2. Johnson CN, et al. ACS Med Chem Lett. 2014 May 23;6(1):25-30.
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