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MELK inhibitor 17

Chemical Structure : MELK inhibitor 17

CAS No.: 2095596-44-2

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MELK inhibitor 17

Catalog No.: PC-35237Not For Human Use, Lab Use Only.

MELK inhibitor 17 is a potent, selective MELK inhibitor with Ki/IC50 of 0.39/3 nM, >100-fold selectivity over CHK1, CAMKK2, NUAK1 and ERK2.

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5 mg $188 In stock
10 mg $298 In stock
25 mg $458 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MELK inhibitor 17 is a potent, selective MELK inhibitor with Ki/IC50 of 0.39/3 nM, >100-fold selectivity over CHK1, CAMKK2, NUAK1 and ERK2.
MELK inhibitor 17 inhibits the expression of the anti-apoptotic protein Mcl-1 and proliferation of TNBC cells exhibiting selectivity for cells expressing high levels of MELK.

Physicochemical Properties

M.Wt 539.636
Formula C31H33N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-5-carboxylate

References

1. Edupuganti R, et al. Bioorg Med Chem. 2017 May 1;25(9):2609-2616.

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