METTL3 PROTAC KH12

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Chemical Structure : METTL3 PROTAC KH12

Catalog No.: PC-23104Not For Human Use, Lab Use Only.

KH12 is a potent METTL3 PROTAC degrader with DC50 of 220 nM in MOLM-13 cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KH12 is a potent METTL3 PROTAC degrader with DC50 of 220 nM in MOLM-13 cells.
KH12 is capable of reversing differentiation and possesses anti-proliferative effects surpassing the small molecule inhibitors on MOLM-13 cells.
KH12 significantly suppresses the growth of various gastric cancer (GC) cells, where the m6A-independent activity of METTL3 plays a crucial role in tumorigenesis.

Physicochemical Properties

M.Wt	1054.36
Formula	C56H77F2N11O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-(8-((6-(4-(4-((4,4-dimethylpiperidin-1-yl)methyl)-2,5-difluorophenyl)-2-oxo-1,4,9-triazaspiro[5.5]undecan-9-yl)pyrimidin-4-yl)amino)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

References

1. Hwang K, et al. Eur J Med Chem. 2024 Sep 6;279:116843.

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