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Chemical Structure : MF-438
CAS No.: 921605-87-0
Catalog No.: PC-20379Not For Human Use, Lab Use Only.
MF-438 (MF438) is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with IC50 of 2.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MF-438 (MF438) is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with IC50 of 2.3 nM.
Co-treatment with cisplatin and the SCD1 inhibitor MF-438 reverts upregulation of lung cancer CSCs markers, strongly synergizes in the inhibition of 3D spheroids formation and induces CSCs apoptosis.
MF-438 exhibits good pharmacokinetics and metabolic stability.
MF-438 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma.
| M.Wt | 421.44 | |
| Formula | C19H18F3N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-(5-Methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]pyridazine |
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1. Léger S, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502.
2. Pisanu ME, et al. Cancer Lett. 2017 Oct 10;406:93-104.
3. Pisanu ME, et al. J Exp Clin Cancer Res. 2018 Dec 17;37(1):318.
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