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Chemical Structure : MF498
CAS No.: 915191-42-3
Catalog No.: PC-42699Not For Human Use, Lab Use Only.
MF498 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist with Ki of 0.74 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MF498 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist with Ki of 0.74 nM.
MF498 inhibits PGE2-induced cAMP accumulation in HEK293 cells stably expressing human EP4 receptor with IC50 of 1.7 nM.
MF498 inhibits inflammation in adjuvant-induced arthritis (AIA) model.
| M.Wt | 603.6853 | |
| Formula | C32H33N3O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Benzeneacetamide, N-[[[4-(5,9-diethoxy-6,8-dihydro-6-oxo-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylphenyl]methyl]sulfonyl]-2-methoxy- |
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1. Clark P. et al. J Pharmacol Exp Ther. 2008 May;325(2):425-34.
2. Burch JD, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2048-54.
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