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MG-101

Chemical Structure : MG-101

CAS No.: 110044-82-1

MG-101 (Calpain inhibitor I, ALLN, MG101)

Catalog No.: PC-45577Not For Human Use, Lab Use Only.

MG-101 (ALLN) is a potent inhibitor of cysteine proteases including calpain I (Ki= 190 nM), calpain II (Ki= 220 nM), cathepsin B (Ki= 150 nM) and cathepsin L (Ki= 500 pM).

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Biological Activity

MG-101 (ALLN) is a potent inhibitor of cysteine proteases including calpain I (Ki= 190 nM), calpain II (Ki= 220 nM), cathepsin B (Ki= 150 nM) and cathepsin L (Ki= 500 pM).
MG-101 activates p53-dependent apoptosis in tumor cell lines.
MG-101 increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro.

Physicochemical Properties

M.Wt 383.5255
Formula C20H37N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-

References

1. Zhang L, et al. J Biol Chem. 1999 Mar 26;274(13):8966-72.

2. Inoue S,et al. J Biol Chem. 1991 Jul 15;266(20):13311-7.

3. Sherwood SW, et al. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3353-7.

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