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Chemical Structure : MG-277
CAS No.: 2411085-89-5
Catalog No.: PC-23062Not For Human Use, Lab Use Only.
MG-277 is a potent molecular glue GSPT1 degrader, effectively degrades GSPT1 protein in a dose- and time-dependent manner in RS4;11 cell line with DC50 of 1.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $558 | In stock | |
| 2 mg | $898 | In stock | |
| 5 mg | Get quote | ||
| 10 mg | Get quote | ||
| 25 mg | Get quote |
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MG-277 is a potent molecular glue GSPT1 degrader, effectively degrades GSPT1 protein in a dose- and time-dependent manner in RS4;11 cell line with DC50 of 1.3 nM.
MG-277 is effective against cancer cell lines carrying wild-type, mutated or deleted p53.
MG-277 potently inhibits cell growth in cancer cell lines in a p53-independent manner.
MG-277 is very potent and effective in inhibition of cell growth in both the RS4;11/IRMI-2 and HL-60 leukemia lines, achieving IC50 values of 3.9 nM and 8.3 nM, respectively.
| M.Wt | 774.72 | |
| Formula | C41H42Cl2FN5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-(5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pentyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide |
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1. Jiuling Yang, et al. J Med Chem. 2019 Nov 14;62(21):9471-9487.
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