Catalog No.: PC-23062Not For Human Use, Lab Use Only.
MG-277 is a potent molecular glue GSPT1 degrader, effectively degrades GSPT1 protein in a dose- and time-dependent manner in RS4;11 cell line with DC50 of 1.3 nM.
MG-277 is a potent molecular glue GSPT1 degrader, effectively degrades GSPT1 protein in a dose- and time-dependent manner in RS4;11 cell line with DC50 of 1.3 nM. MG-277 is effective against cancer cell lines carrying wild-type, mutated or deleted p53. MG-277 potently inhibits cell growth in cancer cell lines in a p53-independent manner. MG-277 is very potent and effective in inhibition of cell growth in both the RS4;11/IRMI-2 and HL-60 leukemia lines, achieving IC50 values of 3.9 nM and 8.3 nM, respectively.
