MG149 | Tip60 (KAT5) inhibitor | Probechem Biochemicals

Chemical Structure : MG149

CAS No.: 1243583-85-8

MG149 (MG-149)

Catalog No.: PC-20867Not For Human Use, Lab Use Only.

MG149 is a selective histone acetyltransferase Tip60 (KAT5) inhibitor with IC50 of 74 uM, with no activity against PCAF and p300.

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100 mg	$458	In stock
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Biological Activity

MG149 is a selective histone acetyltransferase Tip60 (KAT5) inhibitor with IC50 of 74 uM, with no activity against PCAF and p300.
MG149 effectively inhibits acetyltransferase activity of nuclear extracts on the histone H3 and H4 at micromolar concentrations.
MG 149 is competitive with Ac-CoA and noncompetitive with the histone substrate.

Physicochemical Properties

M.Wt	340.46
Formula	C22H28O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-heptylphenethyl)-6-hydroxybenzoic acid

References

1. Massimo Ghizzoni, et al. Eur J Med Chem. 2012 Jan;47(1):337-44.

2. García-González R, et al. Cancers (Basel). 2020 Oct 15;12(10):2986.

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MG149 (MG-149)

Biological Activity

Physicochemical Properties

References

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