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Chemical Structure : MI-223
Catalog No.: PC-62743Not For Human Use, Lab Use Only.
MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents.
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MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents.
MI-223 not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress.
MI-223 exhibits a strong synergy against lung cancer in vivo combined with Olaparib.
| M.Wt | 419.865 | |
| Formula | C23H18ClN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen G, et al. J Clin Invest. 2018 Jan 2;128(1):500-516.
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