Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MI-223
Catalog No.: PC-62743Not For Human Use, Lab Use Only.
MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents.
MI-223 not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress.
MI-223 exhibits a strong synergy against lung cancer in vivo combined with Olaparib.
| M.Wt | 419.865 | |
| Formula | C23H18ClN3O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Chen G, et al. J Clin Invest. 2018 Jan 2;128(1):500-516.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
