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MI-223

Chemical Structure : MI-223

CAS No.: 907166-59-0

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MI-223 (NSC 320223, MI223)

Catalog No.: PC-62743Not For Human Use, Lab Use Only.

MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents.
    MI-223 not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress.
    MI-223 exhibits a strong synergy against lung cancer in vivo combined with Olaparib.

    Physicochemical Properties

    M.Wt 419.865
    Formula C23H18ClN3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-chlorophenyl)-3-[[(Z)-(5-ethoxy-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]quinazolin-4-one

    References

    1. Chen G, et al. J Clin Invest. 2018 Jan 2;128(1):500-516.

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