Chemical Structure : MIF inhibitor Compound 1
CAS No.: 169120-56-3
Catalog No.: PC-24620Not For Human Use, Lab Use Only.
MIF inhibitor Compound 1 (DP00477) is a small molecule allosteric inhibitor of macrophage migration inhibitory factor (MIF) with Ki of 1.3 uM, also is a potent IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor with IC50 of 7.0 uM.
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MIF inhibitor Compound 1 (DP00477) is a small molecule allosteric inhibitor of macrophage migration inhibitory factor (MIF) with Ki of 1.3 uM, also is a potent IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor with IC50 of 7.0 uM.
MIF inhibitor Compound 1 (10 uM) demonstrated selective inhibition activity against HL-60, blocking cell growth by 66%.
M.Wt | 397.80 | |
Formula | C17H11ClF3N3OS | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
3-((2-chlorophenyl)amino)-2-cyano-3-thioxo-N-(3-(trifluoromethyl)phenyl)propanamide |
1. Pantouris G, et al. ACS Omega. 2025 Apr 22;10(17):17441-17452.
2. Röhrig UF, et al. Eur J Med Chem. 2014 Sep 12;84:284-301.
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