MIM1 is a potent, selective small molecule Mcl-1 inhibitor that selectively targets the BH3-binding groove of Mcl-1.
MIM1 effectively competes with FITC-MCL-1 SAHBA and FITC-BID BH3 for MCL-1ΔNΔC binding with IC50 of 4.7 and 4.8 uM, respectively.
MIM1 shows no activity for Bcl-xL; induces caspase activation and leukemia cell death in the specific context of MCL-1 dependence.
