MIPS-19416 | PI3K inhibitor | Probechem Biochemicals

Chemical Structure : MIPS-19416

MIPS-19416 (MIPS19416)

Catalog No.: PC-23003Not For Human Use, Lab Use Only.

MIPS-19416 is a potent dual class I and class II PI3Ks inhibitor with IC50 of 13 nM (PI3KC2α), equal to or more potent than against class I isoforms or against PI3KC2β (IC50=12-94 nM).

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Biological Activity

MIPS-19416 is a potent dual class I and class II PI3Ks inhibitor with IC50 of 13 nM (PI3KC2α), equal to or more potent than against class I isoforms or against PI3KC2β (IC50=12-94 nM).
MIPS-19416 reproduces the platelet cell biology effects of PI3KC2α-deficiency.
MIPS-19416 is potently antithrombotic in human blood ex vivo and mice in vivo and does not affect hemostasis.

Physicochemical Properties

M.Wt	366.38
Formula	C18H18N6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-amino-N-(7,8-dimethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide

References

1. Maria V Selvadurai, et al. Sci Transl Med. 2020 Jul 22;12(553):eaar8430.

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MIPS-19416 (MIPS19416)

Biological Activity

Physicochemical Properties

References

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