MIR17PTi

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Chemical Structure : MIR17PTi

Catalog No.: PC-35397Not For Human Use, Lab Use Only.

MIR17PTi is a novel LNA gapmeR antisense oligonucleotide (LNA-ASO), first-in-class inhibitor of pri-mir-17-92.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MIR17PTi is a novel LNA gapmeR antisense oligonucleotide (LNA-ASO), first-in-class inhibitor of pri-mir-17-92; impairs the proliferation of several cancer cell lines established from both solid and hematologic tumors by on-target antisense activity, and more effectively as compared to miR-17-92s inhibitors; triggers apoptosis via impairment of homeostatic MYC/miR-17-92 feed-forward loops (FFLs) in patient-derived MM cells, induces MYC-dependent synthetic lethality; exerts strong in vivo anti-tumor activity in NOD-SCID mice bearing clinically relevant models of MM.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5'-TACTTGCTTGGCTT-3'

References

1. Morelli E, et al. Blood. 2018 Jul 11. pii: blood-2018-03-836601.

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MIR17PTi

Biological Activity

Physicochemical Properties

References

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