Chemical Structure : MIRO1 Reducer 3
CAS No.:
2624336-91-8
MIRO1 Reducer 3
(MR3, Miro1 Reducer)
Catalog No.: PC-27373Not For Human Use, Lab Use Only.
MIRO1 Reducer 3 (MR3, Miro1 Reducer) is first-in-class small molecule that allosterically disrupt mitochondrial Rho GTPase 1 (MIRO1)-BAX complex, binds C-GTPase domain of the MIRO1, blocks BAX activation and membrane destruction.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MIRO1 Reducer 3 (MR3, Miro1 Reducer) is first-in-class small molecule that allosterically disrupt mitochondrial Rho GTPase 1 (MIRO1)-BAX complex, binds C-GTPase domain of the MIRO1, blocks BAX activation and membrane destruction.
MR3 treatment significantly reduces cell viability across all glioma lines in a dose-dependent manner, does not affect non-glioma cancer or non-cancer cells.
MR3 prevented Antimycin A (AMA)-induced cell death in SNCA-A53T iDAs.
MR3 also rescues DA neuron loss in a Drosophila PD model expressing human SNCA-A53T in vivo.
MR3 (10 uM) altered BAX protein levels in glioma, markedly reduced the number of mitochondria-localized BAX puncta.
MR3 sensitizes glioma cells to ferroptosis and protects Parkinsonian neurons from apoptosis.
MIRO1 Reducer 3 (MR3, Miro1 Reducer) eliminates the Miro1 defect in PD fibroblasts, rescues Parkinson's neurodegeneration.
Physicochemical Properties
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M.Wt
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425.85
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Formula
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C20H17ClFN7O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3-Fluorophenyl)-N'-[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]urea hydrochloride
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References
1. Chung-Han Hsieh, et al. Cell Metab. 2019 Dec 3;30(6):1131-1140.e7.
2. Alva G Sainz, et al. bioRxiv [Preprint]. 2026 Jun 30:2026.06.29.733391.
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