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MIV-247

Chemical Structure : MIV-247

CAS No.: 1352817-76-5

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MIV-247 (MIV 247;MIV247)

Catalog No.: PC-60705Not For Human Use, Lab Use Only.

MIV-247 (MIV247) is a potent, selective, orally active inhibitor of cathepsin S with Ki of 2.1 nM (human cathepsin S).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MIV-247 (MIV247) is a potent, selective, orally active inhibitor of cathepsin S with Ki of 2.1 nM (human cathepsin S).
    MIV-247 displays high selectivity (>200-fold) overs other related cathepsins, inhibits mouse and cynomolgus monkey cathepsin S with Ki of 4.5 and 7.2 nM, respectively.
    MIV-247 attenuates mechanical allodynia alone, and also enhances the effect of gabapentin and pregabalin without increasing side effects in mouse model of neuropathic pain.

    Physicochemical Properties

    M.Wt 391.391
    Formula C17H24F3N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N-(1-(2-amino-2-oxoacetyl)cyclobutyl)-2-(2,2-difluoropropanamido)-3-(1-fluorocyclopentyl)propanamide

    References

    1. Hewitt E, et al. J Pharmacol Exp Ther. 2016 Sep;358(3):387-96.

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