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MIV-711

Chemical Structure : MIV-711

CAS No.:

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MIV-711 (MIV711;MV076159)

Catalog No.: PC-35163Not For Human Use, Lab Use Only.

MIV-711 (MIV711, MV076159) is a potent, selective cathepsin K inhibitor with Ki of 0.98 nM, displays >1300-fold versus the other human cathepsins.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MIV-711 (MIV711, MV076159) is a potent, selective cathepsin K inhibitor with Ki of 0.98 nM, displays >1300-fold versus the other human cathepsins.
MIV-711 also is a potent inhibitor of dog, guinea pig and rabbit cathepsin K (IC50=1.5/3.3/9.8 nM), but not rat and mouse cathepsin K (IC50=240 and 1000 nM).
MIV-711 shows promise for the treatment of bone and cartilage related disorders in humans such as OA.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

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