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MIV 150

Chemical Structure : MIV 150

CAS No.: 231957-54-3

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MIV 150 (PC-815;MIV150)

Catalog No.: PC-61409Not For Human Use, Lab Use Only.

MIV 150 (PC-815) is a high-affinity, allosteric HIV-1 and HIV-2 reverse transcriptase inhibitor (NNRTI) with EC50 of 1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MIV 150 (PC-815) is a high-affinity, allosteric HIV-1 and HIV-2 reverse transcriptase inhibitor (NNRTI) with EC50 of 1 nM.
    MIV 150 possesses poor oral bioavailability, and demonstrates efficacy when formulated as a topical microbicide (PC-815: Carrageenan gel formulation).

    Physicochemical Properties

    M.Wt 368.4
    Formula C19H17FN4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-Cyano-2-pyridinyl)-N'-[(1S,2S)-2-[6-fluoro-2-hydroxy-3-(1-oxopropyl)phenyl]cyclopropyl]urea

    References

    1. Geitmann M, et al. J Med Chem. 2006 Apr 20;49(8):2367-74.

    2. Fernández-Romero JA, et al. Sex Transm Dis. 2007 Jan;34(1):9-14.

    3. Singer R, et al. Sci Transl Med. 2012 Sep 5;4(150):150ra123.

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