MK-0249 | Histamine H3 antagonist | Probechem Biochemicals

Chemical Structure : MK-0249

Catalog No.: PC-63035Not For Human Use, Lab Use Only.

MK-0249 is a potent, selective and orally active histamine H3 receptor antagonist, with an IC50 of 1.7 nM for human H3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MK-0249 is a potent, selective and orally active histamine H3 receptor antagonist, with an IC50 of 1.7 nM for human H3.

M.Wt	431.459
Formula	C23H24F3N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)-5-(trifluoromethyl)quinazolin-4(3H)-one

1. Brioni JD, et al. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46.

2. James LM, et al. Psychopharmacology (Berl). 2011 Jun;215(4):643-53.

3. Zoethout RW, et al. J Psychopharmacol. 2012 Feb;26(2):292-302.