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Chemical Structure : MK-0429
CAS No.: 227963-15-7
Catalog No.: PC-62001Not For Human Use, Lab Use Only.
MK-0429 is a potent, selective, orally-active nonpeptide αvβ3 integrin inhibitor with IC50 of 0.08 nM in SPAV3 assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $528 | In stock | |
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| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MK-0429 is a potent, selective, orally-active nonpeptide αvβ3 integrin inhibitor with IC50 of 0.08 nM in SPAV3 assay.
MK-0429 displays approximately 100-fold selectivity for αvβ3 over αvβ5 (IC50=10 nM), and no significant activity for the fibrinogen receptor αIIBβ3 (IC50>30 uM).
MK-0429 shows activity in different animal models of bone turnover and has potentiation for the prevention and treatment of osteoporosis.
MK-0429 also reduces melanoma metastasis both in vitro and in vivo.
| M.Wt | 439.51 | |
| Formula | C23H29N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid |
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1. Hutchinson JH, et al. J Med Chem. 2003 Oct 23;46(22):4790-8.
2. Pickarski M, et al. Oncol Rep. 2015 Jun;33(6):2737-45.
3. Zhou X, et al. Pharmacol Res Perspect. 2017 Oct;5(5).
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