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Chemical Structure : MK-0448
Catalog No.: PC-62816Not For Human Use, Lab Use Only.
MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM.
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MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM.
MK-0448 also demonstrates a potent effect on currents associated with other Kv1.x and Kv2.x subunits, such as Kv1.7 and Kv2.1, with IC50 of 72 and 61 nM, respectively.
MK-0448 displays >70-fold concentration than inhibition of IKur.
MK-0448 significantly causes prolongation of the atrial refractory period in normal anesthetized dogs.
| M.Wt | 448.516 | |
| Formula | C24H21FN4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pavri BB, et al. Circ Arrhythm Electrophysiol. 2012 Dec;5(6):1193-201.
2. Loose S, et al. Front Pharmacol. 2014 Mar 4;5:26.
3. Wolkenberg SE, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1062-1069.
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