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Chemical Structure : MK-0536
Catalog No.: PC-60405Not For Human Use, Lab Use Only.
MK-0536 is a potent HIV-1 integrase strand transfer inhibitor with IC50 of 33 nM, 9.5 nM, 40 nM, 20 nM and 237 nM for wt IN, IN Y143R, IN N155H, G118R and IN G140S-Q148H, respectively.
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MK-0536 is a potent HIV-1 integrase strand transfer inhibitor with IC50 of 33 nM, 9.5 nM, 40 nM, 20 nM and 237 nM for wt IN, IN Y143R, IN N155H, G118R and IN G140S-Q148H, respectively.
MK-0536 shows antiviral activities against RAL-resistant viruses with IC50 of 17/6.0/15/20/77 nM in the cell-based assay for WT, IN Y143R, IN N155H, G118R and IN G140S-Q148H viruses.
| M.Wt | 407.826 | |
| Formula | C19H19ClFN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Métifiot M, et al. Antimicrob Agents Chemother. 2011 Nov;55(11):5127-33.
2. Pandey KK, et al. J Biol Chem. 2014 Jul 11;289(28):19648-58.
3. Johnson BC, et al. Antimicrob Agents Chemother. 2012 Jan;56(1):411-9.
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